Do you have any other USB devices on the same buss as the URI?

I have two URIs running on  the same platform as KD8B is using on one of our sites.

It has a USB flash drive for the archivedir and auto-backup. With the stick on the same buss as a URI, sometimes odd stuff happened.

Especially on a reboot sometimes it would find and activate the URI, but the transmitter audio was dropping bits left and right.

Moved the flash drive to another buss and that went away.